New Updates in Pain Healthcare
Brain Imaging Reveals Dynamic Changes Caused by Pain Medicines
November 19, 2013 [Source: American Society of Anesthesiologists (ASA)]
Newswise — CHICAGO – A study in the December issue of Anesthesiology suggests a role for brain imaging in the assessment and potential treatment of chronic pain.
Study Finds Widespread Use of Opioid Medications in Nonsurgical Hospital Patients
November 13, 2013 [Source: Beth Israel Deaconess Medical Center]
BOSTON – Amid a growing climate of concern regarding the overuse of opioid pain medications, a comprehensive analysis of more than 1 million hospital admissions has found that over 50 percent of all nonsurgical patients were prescribed opioids during their hospitalizations -- often at very high doses -- and that more than half of those exposed were still receiving these medications on the day they were discharged from the hospital.
Scientists Identify Clue to Regrowing Nerve Cells
November 7, 2013 [Source: University of Washington in St. Louis]
Researchers at Washington University School of Medicine in St. Louis have identified a chain reaction that triggers the regrowth of some damaged nerve cell branches, a discovery that one day may help improve treatments for nerve injuries that can cause loss of sensation or paralysis.
Pleasure and Pain Brain Signals Disrupted in Fibromyalgia Patients
November 5, 2013 [Source: Arthritis & Rheumatism]
New research indicates that a disruption of brain signals for reward and punishment contributes to increased pain sensitivity, known as hyperalgesia, in fibromyalgia patients. Results published in Arthritis & Rheumatism, a journal of the American College of Rheumatology, suggest that this altered brain processing might contribute to widespread pain and lack of response to opioid therapy in patients with fibromyalgia.
Discovery Channel documentary “PAIN MATTERS: Exploring Chronic Pain in America”
November 2013 [Source: Discovery Channel]
100 million American adults live with chronic pain. That's more than cancer, diabetes and heart disease combined. According to the Institute of Medicine, the high prevalence of chronic pain suggests that the condition is not being adequately managed. Undertreatment of chronic pain creates large costs to the healthcare system and the U.S. economy; we spend more than $560 billion in the U.S. each year on chronic pain-related healthcare costs. Moreover, chronic pain can carry significant physical and emotional burdens.
The Institute of Medicine has called for a better understanding of the impact of pain in an effort to reduce its toll on the people who suffer from it including the impact on their economic, physical and emotional wellbeing.
Pain Matters seeks to do just that. The documentary explores what chronic pain is, its individual and societal impact, and the future of pain management through the stories and struggles of six individuals living with chronic pain and their loved ones, as well as perspective from leading national experts in pain management.
Pain Matters premieres on November 16 and airs again on December 7 and 14.
FDA Approves Extended-Release, Single-Entity Hydrocodone Product
October 25, 2013 [Source: FDA]
The U.S. Food and Drug Administration today approved Zohydro ER (hydrocodone bitartrate extended-release capsules) for the management of pain severe enough to require daily, around-the-clock, long-term treatment and for which alternative treatment options are inadequate.
Zohydro ER, a Schedule II controlled substance under the Controlled Substances Act, is the first FDA-approved single-entity (not combined with an analgesic such as acetaminophen) and extended-release hydrocodone product.
Zohydro ER will offer prescribers an additional therapeutic option to treat pain, which is important because individual patients may respond differently to different opioids.
Zohydro ER is in the class of extended-release/long-acting (ER/LA) opioid analgesics. Due to the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with ER/LA opioid formulations, Zohydro ER should be reserved for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain. Zohydro ER is not approved for as-needed pain relief.
Statement on Proposed Hydrocodone Reclassification
October 24, 2013 [Source: Janet Woodcock, M.D., Director, Center for Drug Evaluation and Research]
In 2009, the U.S. Drug Enforcement Administration (DEA) asked the U.S. Department of Health and Human Services (HHS) for a recommendation regarding whether to change the schedule for hydrocodone combination products, such as Vicodin. The proposed change was from Schedule III to Schedule II, which would increase the controls on these products. Due to the unique history of this issue and the tremendous amount of public interest, we are announcing the agency’s intent to recommend to HHS that hydrocodone combination products should be reclassified to a different and more restrictive schedule. This determination comes after a thorough and careful analysis of extensive scientific literature, review of hundreds of public comments on the issue, and several public meetings, during which we received input from a wide range of stakeholders, including patients, health care providers, outside experts, and other government entities.
FDA Calls for Packaging Changes to Fentanyl Pain Patches
September 23, 2013 [Source: Outpatient Surgery Magazine]
The FDA, citing continued deaths from accidental exposure to fentanyl pain patches, is requiring the manufacturer of Duragesic to print the name and strength of the drug on the patch in long-lasting ink, in a color that is clearly visible to patients and caregivers. The current ink color varies by strength and is not always easy to see, says the FDA. Stronger, longer-lasting ink color will make patches easier to see and minimize risk of accidental exposure.
Novel Treatment of Neuroinflammation Against Low Back Pain by Soluble Fullerol Nanoparticles
September, 2013 [Source: Spine]
Low back pain is one of the most common reasons for clinician visits in Western societies. Symptomatic intervertebral disc degeneration is strongly implicated as a cause of low back pain, as it results in dorsal root ganglion inflammation. The study shows that fullerol has potential to serve as a novel therapeutic agent for low back pain treatment.
Tour de France cyclists live longer than ordinary French men
September 3, 2013 [Source: Heartwire]
The study shows that if you are capable of doing the Tour de France, you might live six to seven years longer than the average individual in the community. The lower mortality rate was significant for deaths resulting from cancer and cardiovascular causes, according to the results of a new study.
Spouses Lose Sleep Over Partners' Chronic Pain, Study Finds
August 16, 2013 [Source: Penn State]
UNIVERSITY PARK, Pa. -- Spouses whose partners suffer from chronic pain may sleep poorly, according to researchers at Penn State, Duke University, the University of Pittsburgh and Kent State University. The researchers also found that the effect of chronic pain on spousal sleep is worse for couples with the closest relationships.
Most Herniated Discs Result from Avulsion, Not Rupture, Suggests Study in Spine
August 14, 2013 [Source: Wolters Kluwer Health: Lippincott Williams & Wilkins]
Herniated discs in the lower (lumbar) spine most often result from avulsion (separation) of the tissue connection between the disc and spinal bone, rather than rupture of the disc itself, according to a study in Spine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.
How Does Acute Pain Become Chronic?
August 13, 2013 [Source: NIH Blog by Dr. Francis Collins]
NIH launched the Grand Challenge on Chronic Pain to investigate how acute pain (which is part of daily experience) evolves into a chronic condition and what biological factors contribute to this transition.
NYSE Closing Bell Rings to Honor Millions with Neuropathy and Neuropathic Pain
August 13, 2013 [Source: The Neuropathy Association]
Neuropathy patients and their loved ones joined The Neuropathy Association on August 12, 2013 to visit the New York Stock Exchange (NYSE) to raise awareness of the growing neuropathy epidemic.
Pharmacy Researcher Fights Cancer, Pain with New Drug
August 13, 2013 [Source: Health Science Center, Texas A & M University]
Few Doctors Have Adequate Training to Effectively Treat Chronic Pain
August 12, 2013 [Source: Henry Ford Health System]
DETROIT – Pain is the most common reason a patient sees a physician but few physicians have received adequate training to help their patients, according to a Henry Ford Hospital article published in the Journal of American Osteopathic Association.
Abdominal Pain in Children Linked to Anxiety and Depression Later in Life
August 12, 2013 [Source: American Academy of Pediatrics]
Children with functional abdominal pain are more likely to have anxiety or depression during childhood, but few studies have looked at what happens when these kids are adults. In "Functional Abdominal Pain in Childhood and Long-term Vulnerability to Anxiety Disorders" in the September 2013 Pediatrics (published online Aug. 12), researchers tracked children with abdominal pain and followed up with them as young adults.
Throbbing Pain Isn't a Matter of the Heart, UF Researchers Find
August 7, 2013 [Source: University of Florida College of Medicine]
Throbbing pain may pound like a heartbeat, but University of Florida scientists have discovered the sensation is all in your head, or more precisely, in your brain waves.
Affordable Care Act information 'For Your Patients'
August 7, 2013 [Source: U.S. Pain Foundation]
The U.S. Pain Foundation has created a page on its website dedicated to Affordable Care Act with a wealth of information including: What to Know about your Navigator, State by State Implementation and much more.
More Opioid Dependence Treatment Needed
August 6, 2013 [Source: Simon Fraser University]
A new report from Simon Fraser University researcher Bohdan Nosyk calls for the expansion of heroin and opioid medical treatment to stem the increase of overdose deaths.
Medtronic Introduces the First and Only Neurostimulation Systems for Chronic Pain Designed for Full-Body MRI Safety*
August 6, 2013 [Source: Medtronic]
With the first U.S. implants of its new RestoreSensor® SureScan® MRI neurostimulation systems, Medtronic, Inc. (NYSE: MDT) is introducing the first and only implantable neurostimulation (also known as spinal cord stimulation, or SCS) systems for use in the treatment of chronic, intractable back and/or limb pain that are approved by the U.S. Food and Drug Administration (FDA) for conditionally safe* full-body Magnetic Resonance Imaging (MRI) under specific conditions.
FDA Warns of Rare Acetaminophen Risk
August 1, 2013 [Source: FDA]
Acetaminophen, a fever and pain reliever that is one of the most widely used medicines in the U.S., can cause rare but serious skin reactions, warns the Food and Drug Administration (FDA).
BIDMC Study Suggests Worsening Trends In Back Pain Management
July 29, 2013 [Source: Beth Israel Deaconess Medical Center]
BOSTON – Patient care could be enhanced and the health care system could see significant cost savings if health care professionals followed published clinical guidelines to manage and treat back pain, according to researchers at Beth Israel Deaconess Medical Center and published in the July 29 issue of JAMA Internal Medicine.
Uncovering a Healthier Remedy for Chronic Pain
July 17, 2013 [Source: Duke University]
A Duke University study revealed that a derivative of DHA (docosahexaenoic acid), a main ingredient of over-the-counter fish oil supplements, can sooth and prevent neuropathic pain caused by injuries to the sensory system. The results appear online in the Annals of Neurology.
New radiofrequency procedure stuns nerves, relieves chronic neck pain longer
July 5, 2013 [Source: University of Florida College of Medicine]
Released in February, Cervicool is the first water-cooled radiofrequency system on the market — meaning it uses water circulation to cool the tubes connected to the radiofrequency needle. This allows for better control, not only when targeting nerves, but also for controlling the temperature of the needle.
Deaths from Prescription Painkiller Overdoses Rise Sharply Among Women
July 2, 2013 [Source: CDC, Morbidity and Mortality Weekly Report (MMWR)]
The number of prescription painkiller overdose deaths increased fivefold among women between 1999 and 2010, according to a Vital Signs report released today by the Centers for Disease Control and Prevention. While men are more likely to die of a prescription painkiller overdose, since 1999 the percentage increase in deaths was greater among women (400 percent in women compared to 265 percent in men). Prescription painkiller overdoses killed nearly 48,000 women between 1999 and 2010.
American Spine & PainMedGroup - Summer Pain News
June 1, 2013 [Source: AS&PMG]
Check out our quarterly newsletter! Learn more about our practice, understanding low back pain, and the basics of pain management.
Provided in PDF format for easy reading and printing.
Nevada Compounding Pharmacy Recalls All Products
April 15, 2013 [Source: FDA]
Fourth large-scale recall since FDA stepped up oversight efforts.
Signature on fMRI May Offer Objective Pain Biomarker
April 11, 2013 [Source: MedScape]
We may finally be touching on an objective measurement tool in evaluating severity of pain.
Functional MRI is a groundbreaking new imaging option to evaluate brain functioning and the
assessment of pain signals to the pain processing centers of the brain. Up until now there has
been no objective tool to measure the severity of pain. This is a very exciting and interesting
area of pain management which will hopefully lead us to further clinical objective tools in the
measurement of pain.
Physician Payment Sunshine: ProPublica Updates Dollars for Doctors Database for 2013
March 12, 2013 [Source: Policy and Medicine]
ProPublica, the team of former investigative reporters has updated its website and is helping several local news agencies produce articles and stories about payments made to physicians.
NUI Galway Researchers Reveal How the Brain Suppresses Pain During Times of Stress
March 6, 2013 [Source: NUI Galway, Ireland]
Researchers at NUI Galway show for the first time that "suppression of pain during times of fear involves complex interplay between marijuana-like chemicals and other neurotransmitters in the amygdala."
Safe, Long-Term Opioid Therapy is Possible
March 5, 2013 [Source: Boston University Medical Center]
A recent article in the Journal of the American Medical Association (JAMA) suggests that prescription opioid abuse can be minimized by using urine drug testing (UDT), pill counts, and reviewing PMP data when available.
Amputee Pain Linked to Brain Retaining Picture of Missing Limb
March 5, 2013 [Source: Oxford University]
Through brain imaging, Oxford University researchers found that "arm amputees experiencing the most phantom limb pain were found to maintain stronger representation of the missing hand in the brain, to the point where it was indistinguishable from people with both hands."
Making an IMMPACT on Pain Research
March 5, 2013 [Source: Pain Research Forum]
Robert H. Dworkin, PhD and Dennis C. Turk, PhD reviewed the past ten years since the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) began and how it has helped clinical trials move from "confusion to consensus." IMMPACT is now part of ACTIION (Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks). AAPM is represented on ACTIION by Ajay D. Wasan, MD, who serves as a Co-Chair on the committee.
DEA National Take-Back Initiative April 27, 2013
February 2013 [Source: DEA]
The next DEA National Prescription Drug Take-Back Day will take place across the country on Saturday, April 27, 2013, from 10:00 AM – 2:00 PM.
Evidence of Small-Fiber Polyneuropathy in Unexplained, Juvenile-Onset, Widespread Pain Syndromes
March 11, 2013 [Source: Pediatrics]
Abstract: OBJECTIVE: We tested the hypothesis that acquired small-fiber polyneuropathy (SFPN), previously uncharacterized in children, contributes to unexplained pediatric widespread pain syndromes.
Considerations in Selecting Rapid-Onset Opioids for the Management of Breakthrough Pain
March 6, 2013 [Source: Journal of Pain Research]
Abstract: Breakthrough pain (BTP) is a transitory pain that occurs despite the use of long-term, around-the-clock analgesia. It is highly prevalent in certain populations and places a significant burden on patients, their families, caregivers, and health-care systems. Despite its prevalence and impact, BTP is sometimes unrecognized and often undertreated. Various formulations of fentanyl – a rapid-onset opioid with short duration of action – are available for the management of BTP.
Epidural Steroid Injections Are Associated With Less Improvement in Patients With Lumbar Spinal Stenosis: A Subgroup Analysis of the Spine Patient Outcomes Research Trial
February 15, 2013 [Source: Spine]
Abstract: Study Design: Subgroup analysis of prospective, randomized database from the Spine Patient Outcomes Research Trial (SPORT). Objective: The hypothesis of this study was that patients who received ESI during initial treatment as part of SPORT (The Spine Patient Outcomes Research Trial) would have improved clinical outcome and a lower rate of crossover to surgery than patients who did not receive ESI. Conclusion: Despite equivalent baseline status, ESIs were associated with significantly less improvement at 4 years among all patients with spinal stenosis in SPORT. Furthermore, ESIs were associated with longer duration of surgery and longer hospital stay. There was no improvement in outcome with ESI whether patients were treated surgically or nonsurgically.
State Estimates of Nonmedical Use of Prescription Pain Relievers
January 8, 2013 [Source: SAMHSA]
The National Survey on Drug Use and Health (NSDUH) combined 2010 and 2011 data which indicate that the rate of past year nonmedical use of prescription pain relievers among those aged 12 or older was 4.6 percent nationally and ranged from 3.6 percent in Iowa to 6.4 percent in Oregon.
Researchers Learn About Pain From Morphine Failures
January 7, 2012 [Source: PsychCentral]
A new study in Nature Neuroscience identified a target pathway to suppress morphine-induced pain and how pain hypersensitivity is caused by tolerance to morphine.
KemPharm, Inc Receives USAN Approval for Nonproprietary Name of Novel Pain Drug Candidate, KP201
January 7, 2013 [Source: KemPharm]
KemPharm's lead pain candidate, KP201, received approval to use the nonproprietary name for "benzhydrocodone" which is composed of hydrocodone chemically bound to a ligand, which offers unique physicochemical and pharmacological attributes that may deliver additional patient benefits, including reduced potential for abuse and reduction or elimination of opioid-induced constipation (OIC).
Impax Starts Selling Generic Oxymorphone Pain Drug
January 4, 2013 [Source: San Francisco Business Times]
The generic form of Endo Pharmaceutical's Opana ER, oxymorphone hydrochloride in extended release tablets, is now available in generic form from Impax Laboratories.
Electric Stimulation of Brain Releases Powerful, Opiate-Like Painkiller
January 2, 2013 [Source: University of Michigan]
New research from the University of Michigan can now explain why sessions of transcranial direct current stimulation on certain regions of the brain provided pain relief. The researchers found that the active release of local mu-opioid needs to bind to the mu-opioid receptor for the opiate to function.
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